|
KMID : 0359920100290050662
|
|
Korean Journal of Nephrology
2010 Volume.29 No. 5 p.662 ~ p.666
|
|
|
A Case of Hemolytic Uremic Syndrome Following Mitomycin C Treated with Long Intensive Plasmapheresis
|
|
Shin Dong-Ho
Lee Mi-Jung
Park Hyun-Sung
Kim Jwa-Kyung
Park Jung-Tak
Chang Tae-Ik
Kang Shin-Wook
Choi Kyu-Hun
Yoo Tae-Hyun
|
|
|
Abstract
|
|
|
|
HUS (Hemolytic Uremic Syndrome) is characterized by acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. In classical HUS, hemorrhagic diarrhea precedes. It is frequently associated with E. Coli O157:H7. Less frequently, HUS may also develop after various treatments such as mitomycin C, cyclosporine, quinine, and ticlopidine. Plasmapheresis is effective in most of classical HUS, which induces a complete remission in most patients with classical HUS. However, this treatment is ineffective in HUS associated with mitomycin C. Although Plasmapheresis is effective on hematologic abnormality in this atypical HUS, chronic renal insufficiency frequently persists as a sequella in HUS associated with mitomycin C. We here report on one patient who developed HUS following mitomycin C therapy due to cervix cancer. The patient was treated with intensive and prolonged plasmapheresis. There was a complete hematologic improvement and steady improvement in renal function.
|
|
|
KEYWORD
|
|
|
Hemolytic-Uremic syndrome, Mitomycin, Plasmapheresis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|